A mixed-methods approach, synthesizing traditional impact data from questionnaires and interviews with social network analyses, provides an emerging view of the multifaceted impact of makerspaces. Open Works, as a single case, exemplifies the potential of makerspaces as a catalyst for economic revitalization in Baltimore, fostering collaboration among artists, entrepreneurs, innovators, industry, and government. Amid increasing demand for local production space driven by a growing interest in creative outlets, entrepreneurial support, supply chain resilience, and expanding access to the means of production, Open Works has emerged as a national leader. Applied impact research provides an advocacy foundation for policies that promote innovation, workforce development, and inclusive economic growth in Maryland and beyond. Open Works' success serves as a model for other makerspaces across the nation and internationally.